初级视觉皮层的光遗传刺激驱动视觉关联皮层中的活动
Michael Ortiz-Rios1,2, Beshoy Agayby1, Fabien Balezeau1
1Biosciences Institute, Henry Wellcome Building, Medical School, Framlington Place, Newcastle upon Tyne, NE2 4HH, UK.
Current research in neurobiology
|July 3, 2023
概括
灵长类人视觉皮层 (V1) 的光遗传刺激精确地准神经回路. 这种方法显示出在非人类灵长类 (NHP) 中绘制大脑连接和功能的潜力,用于翻译神经科学.
科学领域:
- 神经科学是一个神经科学.
- 视觉遗传学 视觉遗传学
- 灵长类动物研究研究
背景情况:
- 光遗传方法对于理解高特异性的大脑功能至关重要.
- 非人类灵长类动物 (NHP) 是翻译神经科学的重要模型.
研究的目的:
- 评估光遗传刺激在猿原始视觉皮层 (V1) 中的选择性.
- 研究V1刺激如何驱动与视觉感知相关的局部层状和广泛的皮质连接.
主要方法:
- 在子子中,背部V1神经元被道罗多普辛感染.
- fMRI,神经生理学和免疫组织化学分析刺激效应.
- 感知决策任务来评估功能结果.
主要成果:
- 对V1的光遗传刺激增加了视觉关联区域 (V2/V3,V4,MT,FEF) 的活性.
- 证实了神经活动和光素表达的光遗传学调制,在V1层4-B中最强.
- 在一只子的感知任务中,刺激引起了烯感知.
结论:
- 光遗传方法可以有效地驱动大型灵长类的皮质电路.
- 对于绘制大脑网络的高功能和空间特异性.
- 强调光遗传学在推动灵长类神经科学研究方面的潜力.
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