在小鼠大脑中的快速局部和缓慢全球神经元组合
Thomas J Delaney1, Cian O'Donnell1,2
1School of Computer Science, Electrical and Electronic Engineering, and Engineering Mathematics, University of Bristol, Bristol, UK.
Network neuroscience (Cambridge, Mass.)
|July 3, 2023
概括
大脑的计算涉及到协同活动的神经元组合. 这项研究揭示了快速时间尺度涉及大脑区域内的局部合奏,而较慢的时间尺度涉及跨越多个区域的合奏,这表明并行处理.
科学领域:
- 神经科学是一个神经科学.
- 计算神经科学是一种神经科学.
- 系统神经科学 系统神经科学
背景情况:
- 神经元组合对于大脑计算至关重要.
- 控制整体局部化的原则 (单个与多个大脑区域) 仍然不清楚.
研究的目的:
- 研究确定神经元组合是否在单个大脑区域内保持局部化或跨越多个区域的原则.
- 分析时间尺度,发射速度和神经元组合组织之间的关系.
主要方法:
- 在清醒的小鼠中,来自九个大脑区域的数百个神经元的同时电生理记录.
- 分析不同时间尺度 (次秒比较慢) 的峰值计数相关性.
- 集成检测算法的应用到神经关联数据.
主要成果:
- 在快速的时间尺度下,尖峰数相关性在大脑区域内比它们之间更强.
- 在较慢的时间尺度上,区域内和区域间的相关性相似.
- 快速时间尺度合奏主要局限于单个大脑区域;慢时间尺度合奏跨越多个区域.
- 高发射率的神经元对显示出比低发射率的神经元对更强的时间尺度依赖的相关性.
结论:
- 神经元组合在不同的时间尺度上表现出不同的空间组织.
- 鼠标大脑可以同时执行快速的局部计算和缓慢的全球计算.
相关概念视频
01:20Anatomy of the Brain: Major Regions
The brain is the most complex organ in the human body. It consists of four main parts: the cerebrum, diencephalon, cerebellum, and brainstem.
The cerebrum is the largest section of the brain and divides into left and right hemispheres, separated by a deep fissure. The cerebral outer layer of grey matter — the cerebral cortex — comprises elevations called gyri and shallow groves called sulci. The inner portion of white matter includes long nerve fibers known as axons, which connect various areas...
The cerebrum is the largest section of the brain and divides into left and right hemispheres, separated by a deep fissure. The cerebral outer layer of grey matter — the cerebral cortex — comprises elevations called gyri and shallow groves called sulci. The inner portion of white matter includes long nerve fibers known as axons, which connect various areas...
01:13Functional Brain Systems: Reticular Formation
The reticular formation is a complex network of gray and white matter located within the brainstem extending from the medulla to the midbrain.
Within the reticular formation, there are several distinct nuclei that can be classified into three broad categories. The Raphe nuclei are located along the midline of the brainstem. They are primarily known for their role in synthesizing and releasing serotonin, a neurotransmitter involved in regulating mood, appetite, sleep, and circadian rhythms. The...
Within the reticular formation, there are several distinct nuclei that can be classified into three broad categories. The Raphe nuclei are located along the midline of the brainstem. They are primarily known for their role in synthesizing and releasing serotonin, a neurotransmitter involved in regulating mood, appetite, sleep, and circadian rhythms. The...
01:31Organization of the Brain
The brain is an integral component of the nervous system and serves as the center for processing sensory inputs, making decisions, and directing bodily actions. This complex organ is organized into three primary sections: the hindbrain, midbrain, and forebrain, each responsible for a range of vital functions.
Hindbrain
The hindbrain, located at the base of the brain, plays a vital role in regulating automatic processes that sustain life. It includes the medulla oblongata, which is essential for...
Hindbrain
The hindbrain, located at the base of the brain, plays a vital role in regulating automatic processes that sustain life. It includes the medulla oblongata, which is essential for...