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基于Treg的免疫疗法用于抗原特异性免疫抑制和稳定耐受性诱导:一个前景

Shimon Sakaguchi^1,2, Ryoji Kawakami², Norihisa Mikami¹

¹Laboratory of Experimental Immunology, Immunology Frontier Research Center, Osaka University, Osaka, Japan.

Immunotherapy advances

|July 3, 2023

概括

富士P3表达调节性T细胞 (Tregs) 对免疫疾病和移植耐受性具有治疗价值. 讨论了基于Treg的免疫抑制和抗原特异性耐受性诱导的策略.

科学领域:

免疫学免疫学免疫学
细胞疗法细胞疗法
移植免疫学移植免疫学

背景情况:

表达FoxP3的调节性T细胞 (Tregs) 对于免疫平衡和耐受性至关重要.
自然存在的Tregs (nTregs) 和诱导的Tregs (iTregs) 都具有显著的治疗潜力.

研究的目的:

审查目前和未来的基于Treg的免疫抑制策略.
确定实现稳定抗原特异性免疫抑制和耐受性诱导的挑战.

主要方法:

在体内,nTregs的扩张使用低剂量的IL-2或IL-2突变蛋白.
在体外扩张ntregs与抗原刺激和IL-2.
用合成受体 (例如,CAR) 设计nTregs以进行有针对性的抑制.
在体外将常规T细胞 (Tconvs) 转化为Treg类细胞.

主要成果:

为了治疗目的,Tregs可以在体内和体外扩展.
工程Treg可以被赋予特定的目标抑制能力.
Tconvs可以转化为稳定,功能性的Treg样细胞.

结论:

基于Treg的疗法在治疗免疫性疾病和促进移植耐受性方面表现有前途.
需要进一步的研究,以克服在临床环境中实现稳定,抗原特异性Treg介导免疫抑制的挑战.

关键词:

采用细胞疗法采用细胞疗法自身免疫性疾病是一种自身免疫性疾病.免疫抑制免疫抑制器官移植器官移植器官移植器官移植监管性T细胞是什么

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