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Updated: Jul 24, 2025

Activation and Measurement of NLRP3 Inflammasome Activity Using IL-1β in Human Monocyte-derived Dendritic Cells
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弗拉盖林诱导的NAIP5激活的结构基础

Bhaskar Paidimuddala1, Jianhao Cao1, Liman Zhang1

  • 1Department of Chemical Physiology and Biochemistry, Oregon Health and Science University, Portland, OR 97239, USA.

bioRxiv : the preprint server for biology
|July 3, 2023
PubMed
概括

NAIP/NLRC4炎症体通过NAIP5结合细菌鞭毛素 (FliC) 的"陷和锁"机制来激活. 这种结合会诱导NAIP5的结构变化,从而启动NLRC4炎症酶激活.

关键词:
细菌感染是一种细菌感染.旗中的旗在NAIP受体中,NAIP受体是在NAIP/NLRC4炎症酶组中.它们是NLR蛋白质.低温电磁波冷却器 (Cryo-EM) 是一个非常好的方法.

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