循环代谢物可能说明酒精消费与心血管疾病的关系
Yi Li1, Mengyao Wang1, Xue Liu1
1Department of Biostatistics, School of Public Health, Boston University, Boston, MA, U.S.
medRxiv : the preprint server for health sciences
|July 3, 2023
概括
长期饮酒与60种不同的代谢物有关. 这些与酒精相关的代谢物表明,与心血管疾病 (CVD) 风险存在复杂的代谢联系.
科学领域:
- 代谢学 代谢学 代谢学
- 心血管疾病研究研究
- 酒精消费研究 饮酒研究
背景情况:
- 对与长期饮酒相关的代谢物特征的理解有限.
- 需要阐明连接酒精消费和心血管疾病 (CVD) 的分子途径.
研究的目的:
- 为了确定与慢性饮酒相关的循环代谢物.
- 调查这些与酒精相关的代谢物和发生的心血管疾病之间的关联.
主要方法:
- 分析了Framingham心脏研究后代队列的2,428名参与者的19年累计平均酒精消费量.
- 利用线性混合模型将酒精摄入量与211种血代谢物相关联.
- 采用考克斯模型来评估与酒精相关的代谢物评分和心血管疾病事件之间的关系.
主要成果:
- 确定了60种与长期饮酒相关的血代谢物.
- 特定的代谢物,如胆固醇和酸丁胆,与酒精摄入量有强烈的积极关联.
- 十种与酒精相关的代谢物与差异性心血管疾病风险有关,构造的代谢物评分显示与发生心血管疾病的相反关联.
结论:
- 发现60种与慢性饮酒有关的代谢物.
- 研究结果表明,酒精摄入量与心血管疾病之间的关系具有复杂的代谢基础.
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