mRNA凝聚液化了细胞质中的流体
Ying Xie1,2, Tiewei Liu1, David Gresham2
1Institute for Systems Genetics, New York University Langone Medical Center, New York, New York, United States.
bioRxiv : the preprint server for biology
|July 3, 2023
概括
细胞压力导致mRNA和蛋白质凝结物形成,增加细胞质流动性. 这种增强的流动性对于细胞应激反应机制和特定细胞器的形成至关重要.
科学领域:
- 细胞生物物理学 细胞生物物理学
- 分子细胞生物学分子细胞生物学
- 生物化学 生物化学
背景情况:
- 细胞质是一种拥挤的环境,影响细胞功能.
- 压力触发了RNA蛋白 (RNP) 凝聚物的形成,如P体和压力颗粒.
- 对于RNP凝聚剂组装对细胞质生物物理性质的影响尚不清楚.
结论:
- 由压力或光引起的RNA凝结使细胞质在中等层流体化.
- 压力诱导的翻译抑制和RNP凝结物形成在调节细胞质物理性质方面发挥着作用.
- 这种调节对于有效的细胞应激反应至关重要.
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