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Updated: Jul 24, 2025

A Multiplexed Luciferase-based Screening Platform for Interrogating Cancer-associated Signal Transduction in Cultured Cells
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A Multiplexed Luciferase-based Screening Platform for Interrogating Cancer-associated Signal Transduction in Cultured Cells

Published on: July 3, 2013

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多重单细胞化学基因组学揭示了针对性治疗反应的激酶依赖性

José L McFaline-Figueroa1,2, Sanjay Srivatsan2,3, Andrew J Hill2

  • 1Department of Biomedical Engineering, Columbia University, New York, NY, USA.

bioRxiv : the preprint server for biology
|July 3, 2023
PubMed
概括

这项研究引入了sci-Plex-Gene-by-Environment (sci-Plex-GxE) 用于大规模单细胞查. 它揭示了质母细胞瘤的适应信号,并建议结合疗法来克服药物耐药性.

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Single-cell Gene Expression Using Multiplex RT-qPCR to Characterize Heterogeneity of Rare Lymphoid Populations10:23

Single-cell Gene Expression Using Multiplex RT-qPCR to Characterize Heterogeneity of Rare Lymphoid Populations

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Targeted Cancer Therapies

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Interactions Between Signaling Pathways

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Two distinct signaling pathways can converge on a single functional unit, which may either be a single protein or a complex of proteins. The response is either functionally distinct or synergistic between the two pathways but different from the response...
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