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Updated: Jul 24, 2025

A High-Throughput Enzyme-Coupled Activity Assay to Probe Small Molecule Interaction with the dNTPase SAMHD1
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在冷EM和结合研究中,含瓜的ssDNA和RNA诱导二度和四度SAMHD1

Benjamin Orris1, Min Woo Sung2, Shridhar Bhat1

  • 1Department of Pharmacology and Molecular Sciences, Johns Hopkins University School of Medicine 725 North Wolfe Street Baltimore, MD 21205.

bioRxiv : the preprint server for biology
|July 3, 2023
PubMed
概括

型SAMHD1酶在单链DNA和RNA中结合关氨酸. 关氨酸结合调节SAMHD1的发生.

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For successful DNA replication, the unwinding of double-stranded DNA must be accompanied by stabilization and protection of the separated single strands of the DNA. This crucial task is performed by single-strand DNA-binding (SSB) proteins. They bind to the DNA in a sequence-independent manner, which means that the nitrogenous bases of the DNA need not be present in a specific order for binding of SSB proteins to it. The binding of SSB proteins straightens single-stranded DNA (ssDNA) and makes...
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