在慢性感染期间,Mycobacterium结核病存在于缺乏溶酶体的单细胞衍生的肺细胞中
Weihao Zheng1, I-Chang Chang1, Jason Limberis2
1University of California, San Francisco.
Research square
|July 3, 2023
概括
结核菌 (Mycobacterium tuberculosis) (Mtb) 通过利用溶酶体贫乏的细胞在肺髓状细胞中持续存在. 用尼洛尼布准这种途径可以改善对Mtb感染的控制.
科学领域:
- 免疫学 免疫学 免疫学
- 微生物学 微生物学
- 细胞生物学 细胞生物学
背景情况:
- 结核菌菌 (Mtb) 慢性感染依赖于髓状细胞的持久性.
- 肺髓状细胞中Mtb逃逸的机制尚不完全理解.
结论:
- Mtb利用溶酶体贫乏的单细胞衍生细胞进行持续性.
- 向溶酶体生物生成为结核病提供了潜在的宿主导疗法.
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