在百万退伍军人计划中,色剂暴露和前列腺癌风险
medRxiv : the preprint server for health sciences
|July 3, 2023
概括
色剂暴露增加了越南战争退伍军人前列腺癌 (PCa) 诊断风险. 即使考虑种族,家族史和遗传因素时,这种关联仍然很重要,尽管与转移或死亡的联系不太清楚.
科学领域:
- 环境流行病学环境流行病学
- 在瘤学瘤学.
- 退伍军人健康 退伍军人的健康
背景情况:
- 色剂是一种已知的致癌物质,已与前列腺癌 (PCa) 风险增加有关.
- 在多元化的美国越南战争退伍军人群体中调查这种关联至关重要,考虑到诸如种族/种族,家族史和遗传倾向等因素.
研究的目的:
- 调查色剂暴露与前列腺癌风险之间的关联.
- 考虑混因素,包括种族/种族,家族史和遗传风险.
- 在多元化的退伍军人群中分析PCa诊断,转移和死亡.
主要方法:
- 利用了百万退伍军人计划 (MVP),这是一个大规模的基于人口的队列研究.
- 包括211,180名男性美国越南战争退伍军人,数据为2011-2021年.
- 评估了使用Cox比例危险模型的色剂暴露,PCa诊断,转移,死亡,种族/种族,家族史和多基因危险评分.
主要成果:
- 暴露于色剂与PCa诊断的风险增加有关 (HR1.04,95% CI1.01-1.06,p=0.003).
- 这种关联主要在非西班牙裔白人男性中观察到.
- 在调整了种族/种族和家族病史后,色剂暴露仍然是PCa诊断的独立风险因素 (HR1.06,95% CI1.04-1.09,p<0.05).
结论:
- 色剂暴露是美国越南战争退伍军人前列腺癌诊断的独立风险因素.
- 该研究强调了在了解PCa风险时考虑人口和遗传因素的重要性.
- 需要进一步的研究来澄清暴露在色剂和PCa转移或死亡之间的关联.
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