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二极性障碍中超秒间隔计时:检查疾病亚型,情绪和药物状态的作用
Victόria A Müller Ewald1,2, Nicholas T Trapp1,2, McCall E Sarrett3
1Department of Psychiatry, The University of Iowa, Iowa City, Iowa, United States of America.
Research square
|July 3, 2023
概括
患有双相情感障碍 (BD) 的人表现出时刻障碍和额头太功率降低. 双相情感障碍中的这些时间缺陷不受BD亚型,情绪或药物的影响.
科学领域:
- 神经科学是一个神经科学.
- 认知心理学 认知心理学
- 精神病学是一个精神病学.
背景情况:
- 认知症状,特别是时机缺陷,在双相情感障碍 (BD) 中很普遍,但仍未得到充分研究.
- 现有研究表明,与对照人群相比,BD患者在各种任务中间隔时间受损.
- BD亚型,情绪状态和药物对这些时间障碍的影响需要进一步调查.
研究的目的:
- 与对照人群相比,研究BD患者的超秒间隔时间和相关的正面乙太振荡.
- 为了检查BD亚型,情绪或抗精神病药物的使用是否会调节时间表现和神经活动.
主要方法:
- 对患有BD和神经类型对照组的患者进行了一次超秒间隔计时任务.
- 脑电图 (EEG) 用于记录大脑活动,重点关注正面的theta振荡.
- 参与者包括患有BD (BDI和BDII) 的个人和对照组,在休息时和计时任务期间分析数据.
主要成果:
- 与对照人群相比,患有BD的个体在超秒间隔时间方面表现出显著的损伤.
- 在任务期间,在BD患者中观察到额头太功率的减少.
- 根据BD亚型,情绪状态或抗精神病药物使用,没有发现时间感知或额头达活性的显著差异.
结论:
- 双极性障碍亚型,情绪状况和抗精神病药物似乎不会改变时间概况或正面的theta活动.
- 时间障碍是BD在不同方式和持续时间中的一致发现.
- 改变时间感知可能代表双相情感障碍的基本认知异常.
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