额头上的对称性,但不是运动和体感官皮质突出
Andrew E Papale1, Madhumita Harish2, Ronald F Paletzki3
1Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA.
bioRxiv : the preprint server for biology
|July 3, 2023
概括
额叶皮层的投影显示了两个大脑半球的精确地形组织,与感觉和运动区域不同. 这表明前额区域可能协调大脑两侧的功能,用于决策和运动规划.
科学领域:
- 神经科学是一个神经科学.
- 系统神经科学 系统神经科学
- 计算神经科学是一种神经科学.
背景情况:
- 新皮质和条状体表现出对感觉和运动功能至关重要的地形组织.
- 感觉和运动区域显示功能侧面化,而参与决策的前部区域可能具有较少的侧面化.
研究的目的:
- 为了研究细胞类型特定的异侧面和异侧面皮质投影的地形精度.
- 为了比较转基因小鼠感觉,运动和前额皮层区域的投影模式.
主要方法:
- 使用了两性转基因小鼠.
- 在皮层区域内,注射部位的位置各不相同.
- 评估了对皮质和条形体的ipsilateral和contralateral投影的地形精度.
主要成果:
- 感官皮层区域显示出强大的地形输出,但较弱,不太精确的对侧投影.
- 运动皮层表现出一些更强但仍然相对较弱的逆侧拓.
- 额叶皮层区域在皮层和条形体的ipsilateral和contralateral投射方面表现出高度的地形相似性.
结论:
- 额叶皮层投射高度地形组织到两个半球,与感觉和运动区域不同.
- 这种在前沿地区的双边组织可能会促进半球间的整合,以实现统一的汽车规划和决策.
- 反侧面的皮质三角体外投影可能会整合基底结环外的信息,从而实现协调的半球作用.
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