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Updated: Jul 24, 2025

Probing the Brain in Autism Using fMRI and Diffusion Tensor Imaging
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Probing the Brain in Autism Using fMRI and Diffusion Tensor Imaging

Published on: September 12, 2011

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研究设计特征增加了跨截面和纵向大脑全局关联研究中的可复制性

Kaidi Kang1, Jakob Seidlitz2,3,4, Richard A I Bethlehem5

  • 1Department of Biostatistics, Vanderbilt University Medical Center.

bioRxiv : the preprint server for biology
|July 3, 2023
PubMed
概括

优化研究设计是改善大脑范围关联研究 (BWAS) 效果大小和可复制性的关键. 具有较大的年龄变异性的纵向设计和特定的采样方案增强了研究结果,为未来的研究提供了关键的指导.

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相关概念视频

Longitudinal Research02:20

Longitudinal Research

Sometimes we want to see how people change over time, as in studies of human development and lifespan. When we test the same group of individuals repeatedly over an extended period of time, we are conducting longitudinal research. Longitudinal research is a research design in which data-gathering is administered repeatedly over an extended period of time. For example, we may survey a group of individuals about their dietary habits at age 20, retest them a decade later at age 30, and then again...
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Longitudinal studies are also widely used in other medical and social science fields. For instance, in cardiovascular research, they can monitor patients' health over decades to identify risk factors for heart disease, such as high cholesterol or smoking, and evaluate the long-term effectiveness of preventive measures. Similarly, in mental health studies, researchers might follow individuals from adolescence into adulthood to understand the development and progression of conditions like...
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Crossover Experiments01:16

Crossover Experiments

Crossover experiments, also called the repeated-measurements design, is a study design in which all experimental units are exposed to all treatments in different periods. Crossover experiments are generally used in psychology, the pharmaceutical industry, agriculture, and medicine.
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Behavior genetics explores how genetic inheritance influences human behavior. It focuses on how genes, passed from parents to offspring, contribute to the development of behavioral traits and tendencies. This branch of genetics seeks to understand the complex interplay between inherited genetic factors and environmental influences in shaping our behaviors.
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Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
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A study design is a set of techniques that allow a researcher to collect and analyze data from different variables defined for a specific research problem. Statistics is commonly for effective study design and more robust experiments,
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