BRAKER3:使用RNA-seq和蛋白质证据与GeneMark-ETP,AUGUSTUS和TSEBRA进行完全自动化的基因组注释
Lars Gabriel1,2, Tomáš Brůna3, Katharina J Hoff1,2
1Institute of Mathematics and Computer Science, University of Greifswald, 17489 Greifswald, Germany.
bioRxiv : the preprint server for biology
|July 3, 2023
概括
BRAKER3是一个新的真核生物基因组注释管道,它集成了RNA-seq和蛋白质数据,以提高准确性. 该工具的性能优于之前的版本和其他现有管道,特别是在复杂的基因组.
科学领域:
- 生物信息学是一种生物信息学.
- 基因组学就是基因组学.
- 计算生物学 计算生物学
背景情况:
- 在大型真核生物基因组中准确的基因预测仍然是由于数据异质性而面临的重大挑战.
- 像BRAKER1和BRAKER2这样的现有注释管道在整合不同类型的证据 (RNA-seq,蛋白质数据) 中存在局限性.
结论:
- BRAKER3为真核生物基因组注释提供了一个准确且易于使用的解决方案.
- 该管道的代码在GitHub上公开提供,并作为Docker容器,促进可访问性.
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