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相关实验视频

Updated: Jul 24, 2025

Protocol for Human Blastoids Modeling Blastocyst Development and Implantation

Protocol for Human Blastoids Modeling Blastocyst Development and Implantation

Published on: August 10, 2022

通过外胚胎利基工程建模人类植入后发育.

Joshua Hislop^1,2,3, Amir Alavi^4,5, Qi Song^4,5

¹Department of Bioengineering, Swanson School of Engineering, University of Pittsburgh, Pittsburgh, PA 15261, USA.

bioRxiv : the preprint server for biology

|July 3, 2023

概括

研究人员开发了一种新的人类干细胞模型iDiscoids,以研究早期植入后的发育. 这一突破可以更好地了解胚胎和胚胎外组织的形成和疾病建模.

科学领域:

发展生物学发展生物学
干细胞生物学干细胞生物学
人类胚胎发生

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Ex Utero Culture of Mouse Embryos from Pregastrulation to Advanced Organogenesis

Ex Utero Culture of Mouse Embryos from Pregastrulation to Advanced Organogenesis

Published on: October 19, 2021

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Last Updated: Jul 24, 2025

Protocol for Human Blastoids Modeling Blastocyst Development and Implantation

Protocol for Human Blastoids Modeling Blastocyst Development and Implantation

Published on: August 10, 2022

Optimized Ex-ovo Culturing of Chick Embryos to Advanced Stages of Development

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Published on: January 24, 2015

Ex Utero Culture of Mouse Embryos from Pregastrulation to Advanced Organogenesis

Ex Utero Culture of Mouse Embryos from Pregastrulation to Advanced Organogenesis

Published on: October 19, 2021

背景情况:

人类胚胎植入对于发育至关重要,但很难在体内进行研究.
现有的干细胞模型缺乏全面的胚胎和非胚胎组织发育.
了解早期植入后是发展毒理学和疾病建模的关键.

结论:

iDiscoids为研究早期植入后发育提供了一个可操作的人类模型.
这个平台促进了对药物测试,发育毒理学和疾病建模的研究.
能够对以前无法获得的人类生活的关键窗口进行机械的洞察.