在毛轴结构,气管发育和支持BicD功能中的BicDR的作用
相关实验视频
Updated: Jul 24, 2025

06:35
In vivo Evaluation of Mucociliary Clearance in Mice
Published on: December 18, 2020
4.4K
Aleksandra Jejina1,2, Yeniffer Ayala3, Greco Hernández3
1Institute of Cell Biology, University of Bern, Switzerland.
bioRxiv : the preprint server for biology
|July 3, 2023
概括
与BicD相关的 (BicDR) 蛋白质支持Drosophila毛皮发育中的BicD功能,在本地运输货物. 在细胞骨组织和远端端局部化方面,BicDR和BicD共同工作.
科学领域:
- 细胞生物学 细胞生物学
- 分子生物学分子生物学
- 发育生物学是发展生物学.
背景情况:
- 细胞极化依赖于不对称的货物定位,通常通过微管体依赖的运输.
- 细胞质体dynein电机,运行在像dynein/dynactin/Bicaudal-D (DDB) 这样的复合体中,驱动负载方向的负载运动.
- 双尾D (BicD) 在DDB机械中充当货物和发动机之间的连接器.
研究的目的:
- 研究BicD相关 (BicDR) 在微管依赖运输中的作用.
- 阐明BicDR对Drosophila毛皮和气管发育的贡献.
- 确定BicDR货物及其与BicD的相互作用.
主要方法:
- 在Drosophila中进行基因分析.
- 蛋白质相互作用研究.
- 对细胞骨组织和蛋白质定位的分析.
主要成果:
- 德洛索菲拉BicDR对于毛皮和背部干部气管发育至关重要.
- BicDR与BicD合作,在发育的毛发中稳定了actin细胞骨架和局部化蛋白质 (Spn-F,Rab6).
- BicDR似乎是当地货物运输的中介,而BicD则负责长途运输.
- 确定EF1γ是BicDR货物,在皮毛形成时与BicD和BicDR发生基因相互作用.
结论:
- BicDR对于BicD在毛毛发育中的功能至关重要.
- 在货物运输和细胞骨组织中,BicDR和BicD具有不同的但互补的作用.
- BicDR促进了当地运输,而BicD则是长途货物交付到远端的关键.
- EF1γ是BicDR的功能性载荷,突出了它在毛发结构中的作用.
相关概念视频
Microtubules in Signaling
1.7K
The primary cilium, made up of microtubules, acts as antennae on the cell surfaces for relaying external stimuli into the cells. These fine hair-like structures are present, generally one per cell. These are non-motile cilia in a 9+0 microtubules arrangement, where the central pair of microtubules are absent. The primary cilia arise from the basal body embedded in the cell membrane. Intraflagellar transport (IFT) carries requisite proteins from the cytoplasm to the cilium because the primary...
1.7K
The Bronchial Tree
3.1K
The human bronchi and bronchial tree play a crucial role in the respiratory system, facilitating the exchange of oxygen and carbon dioxide. Let's delve into the intricate structure and functions of these respiratory components.
The trachea, commonly known as the windpipe, is a tube that connects the larynx (voice box) to the bronchi. At a point called the carina, it bifurcates into two primary bronchi. The right primary bronchus is wider, shorter, and more vertical than the left primary...
The trachea, commonly known as the windpipe, is a tube that connects the larynx (voice box) to the bronchi. At a point called the carina, it bifurcates into two primary bronchi. The right primary bronchus is wider, shorter, and more vertical than the left primary...
3.1K
Trachea
2.3K
The trachea, commonly known as the windpipe, is a vital part of the human respiratory system. It serves as a passageway for air to travel between the larynx and the bronchi, allowing oxygen to reach the lungs. Let's explore its anatomical features, dimensions, layers of the tracheal wall, associated muscles, and the functions of its parts.
Anatomical Features:
Location: About half of the trachea is situated in the neck, anterior to the esophagus, and extends from the larynx (at the level of...
Anatomical Features:
Location: About half of the trachea is situated in the neck, anterior to the esophagus, and extends from the larynx (at the level of...
2.3K
Anatomy of Respiratory System II: Lower Respiratory Tract
1.2K
The lower respiratory tract is anatomically composed of several vital structures, including the larynx, trachea, bronchial tree, alveoli, lungs, and pleurae. Each component has a specific function, and all are intricately connected to ensure efficient respiration.
The Larynx
It is located between the pharynx and the trachea, acts as a passageway for air, and hosts several critical structures, such as the epiglottis, vocal cords, and glottis. The epiglottis acts as a gateway, guiding food to the...
The Larynx
It is located between the pharynx and the trachea, acts as a passageway for air, and hosts several critical structures, such as the epiglottis, vocal cords, and glottis. The epiglottis acts as a gateway, guiding food to the...
1.2K
The Contractile Ring
6.4K
Contractile rings are composed of microfilaments and are responsible for separating the daughter cells during cytokinesis. Contractile ring assembly proceeds along with other cell cycle events; however, very few mechanistic details are known about the timing and coordination of the contractile rings with the cell cycle.
A small GTPase, RhoA, controls the function and assembly of the contractile ring. RhoA belongs to the Ras superfamily of proteins. The activation of formins by RhoA promotes...
A small GTPase, RhoA, controls the function and assembly of the contractile ring. RhoA belongs to the Ras superfamily of proteins. The activation of formins by RhoA promotes...
6.4K
Fimbriae, Pili, and Axial Filaments
59
Fimbriae and pili are specialized bacterial surface structures that play pivotal roles in adhesion, genetic exchange, and motility. Composed primarily of pilin protein, these hairlike appendages are crucial for bacterial survival and pathogenicity in various environments.Fimbriae: Adhesion and PathogenicityFimbriae are fine, filamentous structures measuring 2–10 nanometers in diameter and are densely distributed on the bacterial cell surface. They facilitate bacterial adhesion to abiotic...
59

