生物年龄的遗传架构在九个人类器官系统中
Junhao Wen1, Ye Ella Tian2, Ioanna Skampardoni3
1Laboratory of AI and Biomedical Science (LABS), Keck School of Medicine of USC, University of Southern California, Los Angeles, California, USA.
medRxiv : the preprint server for health sciences
|July 3, 2023
概括
这项研究在超过377,000个人的9个器官系统中绘制了生物衰老的遗传基础. 它确定了与器官特定衰老的遗传联系以及与年龄有关的疾病的潜在干预措施.
科学领域:
- 遗传学和衰老生物学
- 系统生物学 系统生物学
- 基因组医学是基因组医学.
背景情况:
- 了解生物衰老的遗传基础对于解决与年龄相关的疾病至关重要.
- 生物年龄差距 (BAG) 反映了个体相对于时间年龄的衰老速度.
- 研究多器官系统衰老提供了对全身健康和疾病的洞察力.
研究的目的:
- 在九个人类器官系统中描述生物年龄差距 (BAG) 的遗传结构.
- 为了确定与特定器官的生物衰老相关的遗传位置.
- 探索器官间的联系和潜在的治疗点,以改善器官健康.
主要方法:
- 生物年龄差距的全基因组关联研究 (GWAS) 在377,028个人从英国生物银行.
- 分析大脑,眼睛,心血管,肝脏,免疫,代谢,肌肉骨,肺和系统的遗传变异.
- 基因-药物-疾病网络和因果网络的构建,以推断生物学关系.
主要成果:
- 发现了与九个器官系统相关的393个基因组位置-BAG对.
- 在多个器官系统中观察到器官特异性遗传效应和类效应.
- 确定了慢性疾病,生活方式因素 (体重,睡眠) 和多器官BAG之间的潜在因果关系.
结论:
- 遗传因素对多个器官系统的生物年龄差异有显著的影响.
- 这些发现突出了器官特异性和相互关联的遗传因素对衰老的影响.
- 结果表明潜在的治疗策略,包括改变生活方式和药物重新定位,以促进健康的衰老和治疗慢性疾病.
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