金属离子及其对废水中抗菌素耐药性发展的影响
Indorica Sutradhar1, Prinjali Kalyan1, Kelechi Chukwu2
1Department of Biomedical Engineering, Boston University, Boston, MA 02215, USA.
bioRxiv : the preprint server for biology
|July 3, 2023
概括
废水中的微量金属,如铜和铁,可以降低抗生素的有效性,显著增加像大肠杆菌这样的细菌中抗生素耐药性的发展.
科学领域:
- 环境科学 环境科学
- 微生物学 微生物学
- 公共卫生 公共卫生
背景情况:
- 抗菌素耐药性 (AMR) 是一个关键的全球卫生问题.
- 废水环境越来越多地被认为是AMR发展和传播的关键因素.
- 微量金属对废水中抗药耐药性的定量影响仍未得到充分研究.
研究的目的:
- 研究常见抗生素残留物与废水中的金属离子之间的相互作用.
- 确定这些相互作用对大肠杆菌抗生素耐药性的发展的影响.
- 模拟微量金属和多种抗生素残留物对废水环境中的AMR的综合影响.
主要方法:
- 在废水相关度下,实验性地确定抗生素 (西普洛克萨,多西环素) 和金属离子 (铜,铁) 之间的相互作用.
- 评估这些相互作用对大肠杆菌 (Escherichia coli) 抗生素耐药性的发展随着时间的推移的影响.
- 扩展计算模型,包括微量金属和连续流废水系统中的多种抗生素残留效应.
主要成果:
- 发现铜和铁离子在环境相关的度下与西普罗夫洛克萨辛和多克西环素相互作用.
- 这些相互作用,涉及金属离子对抗生素进行化,降低了抗生素的生物活性.
- 建模表明,废水中的金属离子可以显著加快抗生素耐药性大肠杆菌种群的发展.
结论:
- 废水中的微金属与抗生素的相互作用显著影响了AMR的发展.
- 了解这些相互作用对于减轻环境来源的AMR传播至关重要.
- 废水处理策略可能需要考虑金属离子-抗生素共同污染效应.
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