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针对基于废水的测试进行结构化伦理审查

Devin A Bowes^1,2, Amanda Darling³, Erin M Driver¹

¹Biodesign Center for Environmental Health Engineering, The Biodesign Institute, Arizona State University, 1001 S. McAllister Ave, Tempe, AZ, 85287.

medRxiv : the preprint server for health sciences

|July 3, 2023

概括

基于废水的测试 (WBT) 缺乏标准化的伦理审查,可能会损害专业人士和社区. 一个新的框架旨在改善SARS-CoV-2监测WBT中的伦理考虑和数据保护.

科学领域:

公共卫生公共卫生
环境科学环境科学
生物伦理学生物伦理学

背景情况:

针对SARS-CoV-2的废水测试 (WBT) 提供了独立于临床测试的综合性疾病流行数据.
随着WBT的快速扩张,研究和公共卫生目标之间的界限变得模糊,突出了对道德框架的需求.
目前的WBT实践缺乏标准化的道德审查和数据管理,对专业人士和社区构成风险.

研究的目的:

通过开发一个结构化的伦理审查框架来解决WBT的伦理审查缺陷.
创建一个基于共识的框架,包括来自公共卫生指导的11个问题.
追溯评估本框架对已发表的SARS-CoV-2 WBT研究的适用性.

主要方法:

一个跨学科的小组开发了一个11个问题的框架,用于结构化的伦理审查WBT.
该框架使用共识方法推导,优先考虑公共卫生指导.
该框架被追溯应用于53项同行评审的SARS-CoV-2 WBT监测研究 (2020年3月至2022年2月).

主要成果:

由于公布报告中缺少信息,很大一部分 (43%) 的伦理审查问题的答案无法评估.
追溯申请突出了关于WBT研究中关键伦理考虑的报告信息的缺乏.
这表明需要改善关于WBT研究中的伦理方面的沟通和报告.

结论:

假设有一个系统的框架来改善WBT中伦理考虑的沟通.
标准化伦理审查的一致应用将促进对WBT方法的批判性评估和更新.
这将有助于将WBT实践与从业者和监测社区的关切协调一致.

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