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对负面症状的跨诊断方法:探索双相情感障碍的因子结构和负面症状
Henrik Myhre Ihler1, Siv Hege Lyngstad2, Lynn Egeland Mørch-Johnsen1,3
1Norment, Division of Mental Health and Addiction, Oslo University Hospital, Institute of Clinical Medicine, University of Oslo, Oslo, Norway.
双相情感障碍的负面症状表现为表达力减弱和冷漠. 这些症状甚至在安乐死状态下也持续存在,这突显了除了情绪稳定之外,还需要针对性的干预措施.
科学领域:
- 精神病学是一个精神病学.
- 临床心理学 临床心理学
- 神经科学是一个神经科学.
背景情况:
- 负面症状是跨诊断的,影响生活质量和功能.
- 它们往往是由外部因素加剧的,如抑郁症,社会剥夺,抗精神病药物副作用或物质使用.
- 负面症状包括两个方面:表达能力下降和冷漠,这可能需要不同的治疗策略.
研究的目的:
- 为了研究双相情绪障碍中负面症状的潜在因子结构.
- 检查负面症状尺寸与临床/社会人口统计因素之间的关联.
主要方法:
- 在584名患有双相情感障碍的人群中,对阳性和阴性综合征量表 (PANSS) 的探索性和确认性因子分析.
- 相关性和多重等级回归分析.
主要成果:
- 在双相情感障碍中证实了负面症状 (表达能力下降和冷漠) 的二维结构.
- 二极性I诊断和精神病发作史预测了更严重的减弱表达.
- 抑郁症状与负面症状的增加相关,而26.3%的优症患者表现出持久的负面症状.
结论:
- 负面症状的二维结构在精神病和双相情感障碍中是一致的.
- 双相情感障碍的表达减弱可能与精神病责任有关.
- 消极的症状可以持续在euthymic状态,表明需要持续的管理.
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