社会视觉偏好调解皮质厚度对自闭症谱系障碍儿童症状严重性的影响
Jierong Chen1, Zhen Wei1,2, Chuangyong Xu1
1Department of Child Psychiatry and Rehabilitation, Affliated Shenzhen Maternity and Child Healthcare Hospital, Southern Medical University, Shenzhen, China.
Frontiers in psychiatry
|July 3, 2023
概括
自闭症谱系障碍 (ASD) 中的大脑结构的改变可能直接影响症状严重程度或间接通过社会视觉偏好. 这项研究揭示了ASD幼儿的关键神经解剖学联系.
科学领域:
- 神经科学是一个神经科学.
- 发展心理学 发展心理学
- 自闭症研究 自闭症研究
背景情况:
- 自闭症谱系障碍 (ASD) 与改变的大脑解剖学和社会视觉偏好有关,这与症状严重程度相关.
- 很少有研究探讨了ASD中大脑结构,症状严重程度和社会视觉偏好之间的相互作用.
研究的目的:
- 研究大脑结构,社会视觉偏好和ASD幼儿症状严重程度之间的关系.
- 为了阐明潜在的神经机制背后的ASD症状.
主要方法:
- 检查了43名患有自闭症儿童和26名2-6岁的典型发育 (TD) 儿童.
- 评估了社会视觉偏好和皮质形态测量.
- 使用自闭症诊断观察时间表-社会影响 (ADOS-SA-CSS) 的校准严重性得分.
主要成果:
- 在ASD和TD组之间,在社会视觉偏好和皮质形态学上发现了显著的差异.
- 数字社会图像的固定时间减少 (%DSI) 与左侧状回环和右侧胰岛的厚度减少以及下部ADOS-SA-CSS.相关.
- 调解分析表明,%DSI部分调解了神经解剖学变化和症状严重程度之间的联系.
结论:
- 在ASD中非典型的神经解剖学变化可能通过社会视觉偏好直接或间接地影响症状严重程度.
- 这些发现有助于更好地理解导致自闭症的各种神经机制.
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