在患有慢性肝病的患者中,SARS-CoV-2疫苗接种后免疫反应的持久性
Ruixin Song1, Chao Yang2, Qianqian Li2
1The Third Central Clinical College of Tianjin Medical University, Department of Gastroenterology and Hepatology, Tianjin Third Central Hospital, Tianjin Key Laboratory of Extracorporeal Life Support for Critical Diseases, Artificial Cell Engineering Technology Research Center, Tianjin Institute of Hepatobiliary Disease, Tianjin, China.
Frontiers in immunology
|July 3, 2023
概括
补充免疫显著增强和延长慢性肝病 (CLD) 患者的严重急性呼吸道综合征冠状病毒2 (SARS-CoV-2) 抗体耐久性. 这表明,SARS-CoV-2疫苗接种对这一群体来说是安全有效的.
科学领域:
- 免疫学 免疫学 免疫学
- 病毒学 病毒学
- 肝病学 肝病学是一种肝病学.
背景情况:
- 患有慢性肝病 (CLD) 的患者可能有免疫反应的改变.
- 评估CLD患者对SARS-CoV-2疫苗免疫反应的持久性对于公共卫生至关重要.
- 了解免疫受损人群中疫苗的有效性,可以为疫苗接种策略提供信息.
研究的目的:
- 评估在患有CLD的患者中使用SARS-CoV-2疫苗进行基本和强剂免疫接种后免疫反应的持久性.
- 为了比较基本和辅助免疫群体之间的抗体水平和耐久性.
- 为了确定在CLD患者接种疫苗后抗体下降的时间进程.
主要方法:
- 一组313名接受了SARS-CoV-2疫苗的CLD患者被分为基本免疫和强剂免疫组.
- 在免疫接种后的不同时间间隔收集了血清样本.
- 分析了新型冠状病毒中和抗体 (nCoV NTAb) 和尖端受体结合域抗体 (nCoV S-RBD) 的阳性率和标位.
主要成果:
- 在基本免疫接种30天内,nCoV NTAb和nCoV S-RBD的阳性率分别为80.4%和84.8%,在120天内下降至29%和48.4%.
- 补充免疫迅速增加了阳性率,在30天内达到95.2% (nCoV NTAb) 和90.5% (nCoV S-RBD).
- 增强剂后120天 (79.5%的nCoV NTAb,87.2%的nCoV S-RBD) 抗体水平仍然很高,显著延长了负转化时间至266天 (nCoV NTAb) 和329天 (nCoV S-RBD).
结论:
- 在患有慢性结核病的患者中,SARS-CoV-2 基本和增强免疫是安全和有效的.
- 补充免疫显著增强免疫反应,并延长抗体耐用性在CLD患者.
- 这些发现支持了强制性疫苗接种对这一脆弱群体持续保护的重要性.
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