重新定义头发细胞中尖端链接的结构
Veerpal Kaur1, Sanat K Ghosh2, Tripta Bhatia2
1Department of Chemical Sciences, Indian Institute of Science Education and Research Mohali, Mohali 140306, Punjab, India.
Biochemistry
|July 3, 2023
概括
卡德林-23不形成cis二元体,与原卡德林-15不同. 这一发现表明,protocadherin-15 cis二极体诱导尖端链状几何形状,对于听力机械传导至关重要.
科学领域:
- 生物物理学的生物物理.
- 分子生物学分子生物学
- 细胞生物学 细胞生物学
背景情况:
- 尖端环节是卡德林-23和原卡德林-15.5的双螺旋四旋复合体.
- 这些结构对于听力和平衡中的机械传导至关重要.
- 已了解protocadherin-15的cis二元构造,但cadherin-23的结构仍然难以捉摸.
研究的目的:
- 为了研究cadherin-23的cis二元构造.
- 为了阐明底层尖端链组件和几何学的分子机制.
主要方法:
- 溶液中的蛋白质和脂质膜上的蛋白质的光诱导交联.
- 使用脂质囊泡测量相互作用动力学的聚合测试.
主要成果:
- 没有发现cadherin-23 cis二元体的证据.
- 尖链阴素的cis二元体之间的聚合明显比二元体-单元体相互作用慢得多.
- 尖端链接重新关联在protocadherin-15 cis二极体和cadherin-23单体之间动力学上受到青.
结论:
- 卡德林-23不形成圆二元体.
- Protocadherin-15 cis二元可能会诱导尖端链接的螺旋形几何形状.
- 在尖端链路形成之前,cadherin-23 仍然是单质的.
相关概念视频
Hair Cells
40.7K
Hair cells are the sensory receptors of the auditory system—they transduce mechanical sound waves into electrical energy that the nervous system can understand. Hair cells are located in the organ of Corti within the cochlea of the inner ear, between the basilar and tectorial membranes. The actual sensory receptors are called inner hair cells. The outer hair cells serve other functions, such as sound amplification in the cochlea, and are not discussed in detail here.
40.7K
The Cochlea
45.2K
The cochlea is a coiled structure in the inner ear that contains hair cells—the sensory receptors of the auditory system. Sound waves are transmitted to the cochlea by small bones attached to the eardrum called the ossicles, which vibrate the oval window that leads to the inner ear. This causes fluid in the chambers of the cochlea to move, vibrating the basilar membrane.
45.2K
Auditory Pathway
5.5K
Auditory pathways constitute the complex neural circuits responsible for transmitting and interpreting auditory information from the peripheral auditory system to the brain. Sound waves are initially captured by the outer ear, funneled through the ear canal, and reach the tympanic membrane (eardrum). These vibrations are transmitted via the middle ear's ossicles to the inner ear's cochlea.
When viewed cross-sectionally, the cochlea reveals the scala vestibuli and scala tympani flanking...
When viewed cross-sectionally, the cochlea reveals the scala vestibuli and scala tympani flanking...
5.5K
Accessory Structures of the Skin: Hair and Hair Follicles
2.4K
Hair and hair follicles are integral components of the integumentary system. Hair is a filamentous structure composed mainly of a protein called keratin. It is found on the surface of the skin throughout the body, except for areas such as the palms of the hands and soles of the feet.
Hair is a keratinous filament growing out of the epidermis. It is primarily made of dead, keratinized cells. Hair strands originate at the epidermal penetration called the hair follicle. The hair shaft is the part...
Hair is a keratinous filament growing out of the epidermis. It is primarily made of dead, keratinized cells. Hair strands originate at the epidermal penetration called the hair follicle. The hair shaft is the part...
2.4K
Anatomy of the Ear
8.5K
Auditory sensation, commonly called hearing, involves the transformation of sonic waves into neural impulses facilitated by the structures of the auditory organ. The prominent, flesh-like structure on the side of the head, called the auricle, directs sound waves towards the auditory canal. The auricle is often mislabeled as the pinna, a term more aligned with mobile structures like a feline's external ear. The auditory canal penetrates the cranium via the external auditory meatus of the...
8.5K
Unrenewable Cells
2.3K
In humans, the photoreceptor cells of the eye and sensory hair cells of the ear lack stem cells. These cells are thus unrenewable and cannot be replaced when they are damaged or destroyed.
Photoreceptors
The retina is composed of several layers and contains specialized cells called photoreceptors. The photoreceptors (rods and cones) change their membrane potential when stimulated by light energy. There are two types of photoreceptors—rods and cones—which differ in the shape of...
Photoreceptors
The retina is composed of several layers and contains specialized cells called photoreceptors. The photoreceptors (rods and cones) change their membrane potential when stimulated by light energy. There are two types of photoreceptors—rods and cones—which differ in the shape of...
2.3K


