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Updated: Jul 24, 2025

Large-Scale Multi-Omics Genome-Wide Association Studies Mo-GWAS: Guidelines for Sample Preparation and Normalization
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全基因组关联研究确定了多个HLA位点,用于对沙尔科毒症的敏感性

Shu-Yi Liao1,2,3, Sean Jacobson1, Nabeel Y Hamzeh4

  • 1Department of Medicine, National Jewish Health, Denver, CO 80206, USA.

Human molecular genetics
|July 3, 2023
PubMed
概括

这项研究确定了新的遗传变异和人类白细胞抗原 (HLA) 基因,与欧洲裔美国人和非洲裔美国人群中的沙尔科毒症易感性有关. 这些发现突出显示了HLAII类基因在肉类发病中的作用.

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Genome-wide Association Studies-GWAS01:11

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Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
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A single nucleotide polymorphism or SNP is a single nucleotide variation at a specific genomic position in a large population. It is the most prevalent type of sequence variation found in the human genome. Point mutations that occur in more than 1% of the population qualify as SNPs. These are present once every 1000 nucleotides on an average in the human genome. Replacement of a purine with another purine (A/G) or a pyrimidine with another pyrimidine (C/T) is known as a transition. In contrast,...
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