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Updated: Jul 24, 2025

Characterizing Mutational Load and Clonal Composition of Human Blood
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Characterizing Mutational Load and Clonal Composition of Human Blood

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通过单细胞分析的克隆动态和拷贝数变异,用于骨髓增殖性新生瘤的白血病进化

Laura Calabresi1,2, Chiara Carretta3,4, Simone Romagnoli1,2

  • 1Center Research and Innovation of Myeloproliferative Neoplasms (CRIMM), Azienda Ospedaliera-Universitaria Careggi, Florence, Italy.

American journal of hematology
|July 3, 2023
PubMed
概括

骨髓增殖性瘤 (MPN) 爆发期 (BP) 转变涉及增加克隆复杂性和副本数变异 (CNVs). EZH2失调是关键因素,表明MPN-BP的潜在治疗点.

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