在患有精神病REM睡眠行为障碍的患者中,家族性α-synucleinopathy谱的特征
Jing Wang1,2,3, Siu Ping Lam1, Bei Huang1
1Li Chiu Kong Family Sleep Assessment Unit, Department of Psychiatry, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong SAR, China.
Journal of neurology, neurosurgery, and psychiatry
|July 3, 2023
概括
患有REM睡眠行为障碍 (RBD) 和精神疾病的患者表现出对α-synucleinopathies的家族性倾向. 这表明精神病患者的RBD可能表明潜在的神经退行性疾病.
科学领域:
- 神经学 神经学
- 睡眠医学 睡眠医学
- 遗传学 是一个遗传学.
背景情况:
- 快速眼动 (REM) 睡眠行为障碍 (RBD) 是像帕金森病 (PD) 这样的α-synucleinopathies的早期迹象.
- 目前尚不清楚精神疾病中RBD (psy-RBD) 是良性副作用还是α-synucleinopathy的早期迹象.
- 这项研究调查了患有精神RBD的患者的α-synucleinopathy家族风险.
研究的目的:
- 为了确定患有psy-RBD的患者是否有家族性倾向于α-synucleinopathy.
- 为了比较精神RBD患者的亲属与对照者的α-synucleinopathy频谱特征风险.
主要方法:
- 采用了一个病例-控制-家庭研究设计.
- 利用家族史和家庭研究方法来评估α-synucleinopathy频谱特征.
- 心理RBD患者的第一级亲属 (FDR) 的风险比较,精神病学对照和健康对照.
主要成果:
- 精神RBD患者的一级亲属表现出增加的α-synucleinopathy特征,包括RBD,抑郁症和帕金森症.
- 具体来说,与健康对照者相比,精神RBD亲属的RBD诊断,REM相关的电肌图学活动和PD/痴呆症诊断风险更高.
- 精神科对照的亲属只显示了抑郁症的家族聚合.
结论:
- 患有psy-RBD的患者表现出对α-synucleinopathy的家族性倾向.
- 与严重抑郁症一起发生的RBD可能表明主要抑郁症的亚型与潜在的α-synucleinopathy.
- 这些发现强调了在患有精神RBD的患者中考虑α-synucleinopathy的重要性.
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