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Updated: Jul 24, 2025

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在低微分子度下,Englerin A 抑制T型电压通道

Barbara Wardas1, Jochen G Schneider1, Norbert Klugbauer1

  • 1Experimentelle und Klinische Pharmakologie und Toxikologie/PZMS, Universität des Saarlandes, Homburg, Germany (B.W., V.F., A.B.); Department of Internal Medicine II, Universitätsklinikum des Saarlandes und Medizinische Fakultät der Universität des Saarlandes, Homburg, Germany (J.G.S.); Luxembourg Centre for Systems Biomedicine, University of Luxembourg, Luxembourg, Luxembourg (J.G.S.); and Experimentelle und Klinische Pharmakologie und Toxikologie, Medizinische Fakultät, Albert-Ludwigs-Universität Freiburg, Freiburg, Germany (N.K.).

Molecular pharmacology
|July 3, 2023
PubMed
概括

作为TRPC通道激动剂的Englerin A (EA) 还可以抑制电压通道 (CaV),包括L型CaV1.2和T型CaV3通道. 这一发现揭示了EA超出其已知的TRPC通道活动的新治疗潜力.

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