从中枢杏仁体到副手臂核的动态发射调节
Hideki Funahashi1,2, Darya Pavlenko1, Kent Sakai1
1Dr. Phillip Frost Department of Dermatology and Cutaneous Surgery and Miami Itch Center, University of Miami Miller School of Medicine, Miami, FL 33136.
概括
中枢杏仁体 (CeA) 中的产生激素的神经元向准核 (PBN) 发射,并调节. 刺激这些dynorphinergic CeA-to-PBN投射会减少 PBN 中的划伤和神经元活动.
科学领域:
- 神经科学是一个神经科学.
- 和疼痛信号 和疼痛信号
- 感官处理 感官处理
背景情况:
- 杏仁体对于处理情绪,和疼痛至关重要.
- 杏仁体 (CeA) - 骨核 (PBN) 途径的中央核与疼痛调节有关.
- 这种CeA-PBN通路在信号传递中的作用在很大程度上仍未被探索.
研究的目的:
- 为了研究出产诺芬 (Pdyn) 阳性 (Pdyn+) CeA-to-PBN预测在调节中的作用.
- 为了确定这种途径的光遗传学操纵是否会影响与有关的行为和神经元活动.
主要方法:
- 利用prodynorphin (Pdyn) -Cre小鼠进行有针对性的光遗传学操纵.
- 光遗传刺激的Pdyn+杏仁体神经元和Pdyn+ CeA-to-PBN投影.
- 在PBN中,测量了对刺激 (希斯胺,氨酸) 的行为,并评估了神经元激活 (Fos表达).
主要成果:
- 对Pdyn+CeA-to-PBN投影的光遗传学刺激显著抑制了由组胺和氨酸引起的痕.
- 刺激抑制了PBN中Fos阳性神经元的增加,这种增加是由诺基因诱导的.
- 刺激增强了热和机械疼痛值,但没有改变类似焦虑的行为.
结论:
- 从CeA到PBN的动态发射在调节信号方面发挥着至关重要的作用.
- 这一途径有效地抑制PBN中的引起的和相关的神经元活动.
- 这些发现揭示了一种新的控制机制,涉及CeA-PBN通路.
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