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MAPK/MAK/MRK重叠激酶 (MOK) 通过Brd4控制微质炎症/I型IFN反应,并参与ALS

Jesús A Pérez-Cabello1,2, Lucía Silvera-Carrasco1,2, Jaime M Franco1

  • 1Centro Andaluz de Biología Molecular y Medicina Regenerativa, Universidad de Sevilla-Consejo Superior de Investigaciones Científicas, Seville 41092, Spain.

Proceedings of the National Academy of Sciences of the United States of America
|July 3, 2023
PubMed
概括

肌缩侧面硬化症 (ALS) 涉及微质细胞的有害炎症. 这项研究确定了MAPK/MAK/MRK重叠激酶 (MOK) 作为这种神经炎症的关键调节剂,为ALS提供了潜在的治疗标.

关键词:
肌缩侧面硬化症 (ALS) 是一种疾病.格利亚 (Glia) 是一个.神经退行性疾病是一种神经退行性疾病.神经炎症是一种神经炎症.信号酶的信号传递

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