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Updated: Jul 24, 2025

Deciphering the Structural Effects of Activating EGFR Somatic Mutations with Molecular Dynamics Simulation
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由胺醇-1 (BUB1) 不受抑制的芽通过减少EGFR内部化来调节EGFR信号传递

Shyam Nyati1,2, Grant Young1, Corey Speers1,3

  • 1Department of Radiation Oncology, University of Michigan, Ann Arbor, MI 48109, USA.

Aging
|July 3, 2023
PubMed
概括

布布1通过控制EGFR的激活,内化和降解来调节表皮生长因子受体 (EGFR) 信号传递. 抑制BUB1激酶活性会影响EGFR信号通路,而不会影响其他受体氨酸激酶.

关键词:
一个BUB1一个BUB1欧洲农业基金会 (EGFR) 是一个基金.癌症 癌症 癌症 癌症 癌症细胞内的形成 细胞内的形成信号传输 信号传输

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