患有或没有风湿性疾病的生殖年龄妇女产后抑郁症:基于人口的匹配队列研究
Divya Shridharmurthy1, Kate L Lapane2, Anthony P Nunes2
1D. Shridharmurthy, MMBS, MPH, Division of Epidemiology, Department of Population and Quantitative Health Sciences, and Clinical and Population Health Research Program, Graduate School of Biomedical Sciences, UMass Chan Medical School, Worcester, Massachusetts.
The Journal of rheumatology
|July 3, 2023
概括
与没有类风湿性疾病的女性相比,患有轴性脊髓关节炎,牛皮性关节炎或类风湿性关节炎的女性面临着更高的产后抑郁症风险. 早期识别和支持对于母亲的心理健康至关重要.
科学领域:
- 类风湿病学 类风湿病学
- 产科 产科 产科 产科 产科
- 精神病学是一个精神病学.
背景情况:
- 产后抑郁症 (PPD) 是影响母亲心理健康的一个重大问题.
- 患有慢性类风湿性疾病的女性可能具有PPD的独特风险因素.
研究的目的:
- 调查轴性脊椎关节炎 (axSpA),牛皮关节炎 (PsA) 或类风湿性关节炎 (RA) 的女性中PPD的发生率.
- 为了比较这些女性的PPD率与没有风湿性疾病 (RD) 的匹配队列.
主要方法:
- 2013-2018年IBM MarketScan商业索赔和遭遇数据库的回顾性分析.
- 包括患有axSpA,PsA或RA的孕妇,根据年龄和先前的抑郁病史,与最多四个没有RD的对照进行匹配.
- 用于评估产后一年内PPD风险的Cox脆弱性比例危险模型.
主要成果:
- 这项研究包括2667名患有axSpA/PsA/RA的妇女和10668名对照.
- 在 axSpA/PsA/RA 队列中,有 17.2% 的患者出现 PPD,而非 RD 组的患者为 12.8%.
- 患有 axSpA/PsA/RA 的女性对于 PPD 的调整后危险比率 (aHR) 显著更高,为 1.22 (95% CI 1.09-1.36).
结论:
- 患有axSpA,PsA或RA的生殖年龄的妇女经历了显著更高的产后抑郁症率.
- 这些发现强调了需要提高意识和针对性查PPD在这个患者群体.
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