在产后发育过程中,由 pituitary activins 调节益生素分泌的性别特异性调节
Alejandra Abeledo-Machado1, Dana Bornancini1, Milagros Peña-Zanoni1
1Instituto de Biología y Medicina Experimental (IBYME), CONICET, Buenos Aires, Argentina.
The Journal of endocrinology
|July 3, 2023
概括
下垂体活性素调节发育中的大鼠的益生菌分泌,具有性别特异性的影响. 这种内垂体机制在生命早期影响了前素水平的性别差异.
科学领域:
- 内分泌学 在内分泌学.
- 神经科学是一个神经科学.
- 发展生物学 发展生物学
背景情况:
- 在老鼠中,血清前素水平从出生到成年期都会上升,而雌性老鼠的血清前素水平从出生到成年期都会上升.
- 脑下垂体/淋巴腺因子不能完全解释观察到的性别差异在益生素调节.
- 实验室研究表明,在早期发育过程中,内因子控制着前素分泌.
研究的目的:
- 调查垂体活性素在调节大鼠出生后发育期间的益生菌分泌中的作用.
- 阐明参与活性因介导的益乳素调节的性别特异机制.
- 确定活性素在血清前性蛋白观察到的性别差异中的参与.
主要方法:
- 在11日,23日和45日产后的雄性和雌性斯普拉格 - 达利大鼠中分析了激素子单元和受体的垂体表达.
- 评估了激素对前素分泌和Pit-1表达的影响.
- 研究了pSMAD和p38MAPK通路的参与.
主要成果:
- 下垂体活激素和受体表达在出生后11天的雌性大鼠中达到峰值,随着年龄的增长而下降,并在23日消除性别差异.
- 到第45天,男性的抑制蛋白β (Inhbb) 表达显著增加,在成年后成为主要的.
- 阿提通过Pit-1下调抑制了益生菌,涉及pSMAD和p38MAPK通路;p-p38MAPK在11天的雌性乳糖培养物中高,随着年龄的增长而下降.
结论:
- 垂体活性蛋白对前素分泌的调节是性别特异的,在出生后的第一周内在女性中更为明显,并且随着年龄的增长而减少.
- 这种内调节有助于在产后发育期间血清前素水平的性别差异.
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