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针对性交付的抗癌药物装载充电PLGA聚合物纳米粒子使用静电场的目标交付

Seyyed Hossein Miraghaie^1,2,3, Ashkan Zandi^2,4, Zahra Davari^2,3

¹Department of Polymer Engineering, Kish International Campus, University of Tehran, Kish Island, 79416-55664, Iran.

Macromolecular bioscience

|July 3, 2023

概括

纯正静电电荷 (PPEC) 通过吸引药物载荷纳米粒子 (DLN) 到瘤来增强向化疗. 这种方法实现了有效的癌症治疗,药物剂量显著降低,副作用最小.

科学领域:

生物医学工程生物医学工程
纳米技术纳米技术
在瘤学瘤学.

背景情况:

侵袭性癌细胞激烈地增殖和代谢.
向药物输送的目的是尽量减少非向器官的副作用.
目前的化疗通常涉及高度药物和全身毒性.

研究的目的:

调查使用纯正静电电荷 (PPECs) 针对药物载荷纳米粒子 (DLNs) 的定向输送.
在小鼠模型中评估PPEC辅助化疗的疗效和安全性.
评估药物的受控释放,从DLN上加盖了聚乳合糖化物 (PLGA) 和聚乙烯醇 (PVA) 的药物.

主要方法:

使用PLGA和PVA开发的DLN,以稳定的负电荷为特征.
在小鼠模型中,应用了一个带电的贴片,将PPEC送到瘤区域.
使用生物化学,放射学和组织学方法测试药物释放和瘤抑制.
在非向器官 (老鼠肝) 中评估药物度和副作用.

主要成果:

由于稳定的负收费,DLN对PPEC具有很强的吸引力.
在瘤部位观察到可控,有针对性的药物释放.
与传统化疗 (2 mg kg-1) 相比,通过较低度 (0.75 mg kg-1) 实现显著的药物输送.
在非向器官中,已被证明是微不足道的副作用.

结论:

PPECs促进了DLN的向传递和受控释放到瘤部位.
这种PPEC辅助的方法可以有效地进行局部化疗,降低药物剂量和最小的毒性.
PPECs显示出先进的向化疗具有更好的安全性概况的显著潜力.

关键词:

动物研究动物研究癌症癌症癌症癌症癌症带电的聚合物纳米粒子.静电场是一种静电场.优化的化疗化疗.有针对性的药物输送.

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