在调节肠道微生物群和新陈代谢方面,Lactobacillus sakei L-7的益生菌潜力很大
1School of Chemical Engineering and Technology, Tianjin university, Tianjin 300350, the People's Republic of China.
Microbiological research
|July 3, 2023
概括
从香肠中分离出来的 Lactobacillus sakei L-7 显示出强大的益生菌潜力. 这种有益的细菌增强了肠道微生物群,增加了良好的代谢物,并减少了炎症,这表明它可以作为一种新的益生菌.
科学领域:
- 微生物学 微生物学
- 胃肠病学 胃肠病学
- 免疫学 免疫学 免疫学
背景情况:
- 肠道微生物群在宿主健康和疾病中起着至关重要的作用.
- 益生菌研究旨在确定有益于人类健康的微生物资源.
- 乳酸菌萨基L-7从自制香肠中分离出来,作为潜在的益生菌候选者.
研究的目的:
- 为了评估Lactobacillus sakei L-7的益生菌特性.
- 评估L. sakei L-7对肠道微生物群和宿主健康的体外和体内影响.
主要方法:
- 在体外试验中评估了L. sakei L-7的活力,疏水性和聚合性.
- 在C57BL/6J小鼠中,给予L. sakei L-74周.
- 进行了16S rRNA基因测序,代谢学和炎症性细胞因子分析.
主要成果:
- 在实验室中,L. sakei L-7表现出高活力和强大的粘附性质.
- 口服L. sakei L-7增加了肠道微生物群的丰富性和有益细菌的丰富性 (Akkermansia,Allobaculum,Parabacteroides).
- 有益的代谢物 (胺黄油酸,多可沙赫萨酸) 增加,而有害的代谢物 (神素,酸) 减少. 血清炎症性细胞因子 (IL-6,TNF-α) 减少.
结论:
- 乳酸菌萨基L-7显示出显著的益生菌潜力.
- 这种菌株可以通过调节微生物群组成和代谢物概况来促进肠道健康.
- L. sakei L-7 可能有助于减少炎症反应,表明其作为功能性食品成分的潜力.
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