使用治疗前的de novo威胁条件结果来预测对DCS治疗反应的治疗反应,增加基于暴露的CBT
Rebecca E Lubin1, Hayley E Fitzgerald1, David Rosenfield2
1Department of Psychological and Brain Sciences, Boston University, 900 Commonwealth Ave, 2nd Fl, Boston, MA, 02215, USA.
Journal of psychiatric research
|July 3, 2023
概括
D-cycloserine (DCS) 增强的认知行为疗法 (CBT) 显示出不同的结果. 威胁条件的灭绝和保留预测了DCS的好处,帮助那些学习较差的人.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 行为科学 行为科学
背景情况:
- 对d-cycloserine (DCS) 用于增强基于暴露的认知行为疗法 (CBT) 的研究对焦虑和恐惧障碍产生了不一致的结果.
- 正在寻找DCS疗效的调节剂,因为发现的结果是可变的.
研究的目的:
- 评估威胁条件化结果作为治疗对基于暴露的CBT的治疗反应的预测因素,有或没有DCS增强用于社会焦虑障碍.
- 为了确定DCS增强效益的潜在生物标志物.
主要方法:
- 一项随机临床试验的二次分析,该试验涉及59名患有社会焦虑症的门诊患者.
- 评估新的威胁条件的结果:威胁的获得,灭绝和灭绝的保留.
- 在调节和治疗过程中评估皮肤导电性反应 (SCR) 和预期寿命等级.
主要成果:
- 较差的灭绝和灭绝保留,通过差异性皮肤导电性反应 (SCR) 测量,预测了对DCS增强的改善临床反应.
- 对预期评级没有观察到缓和效应,这表明DCS可能有选择性地帮助下级学习.
- 威胁条件化结果没有预测独立于DCS增强的基于暴露的CBT的反应.
结论:
- 由于威胁条件导致的灭绝和灭绝保留可以作为DCS增强疗效的预处理生物标志物.
- 这些发现有助于了解DCS在治疗社会焦虑障碍中的有效性.
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