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孕前暴露于per-和多基基物质和婴儿睡眠障碍:一个前性队列研究

Yun Huang¹, Fang Fang², Yan Chen³

¹Ministry of Education-Shanghai Key Laboratory of Children's Environmental Health, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Environment international

|July 3, 2023

概括

产前暴露于per-和多基基物质 (PFAS) 与婴儿睡眠问题有关. 这项研究发现PFAS与婴儿严重睡眠障碍,打和夜间觉醒的风险增加有关.

科学领域:

环境健康环境健康
发育儿科发育儿科
毒理学毒理学毒理学

背景情况:

产前暴露在per-和多基基物质 (PFAS) 中可能会影响胎儿的大脑发育.
关于产前PFAS暴露与婴儿睡眠模式之间的联系的研究有限.

研究的目的:

调查 PFAS 产前暴露与婴儿生命第一年的睡眠障碍之间的关系.
分析PFAS对婴儿睡眠结果的单个和混合影响.

主要方法:

一项针对4127名孕妇的前性队列研究 (上海分娩队列).
在怀孕的第一季度,在母亲血清中量化了十种PFAS.
使用6个月和12个月的婴儿睡眠简要问卷评估睡眠质量.
统计分析包括多重线性回归,多项逻辑回归,基于量子的g计算和概括估计方程 (GEE) 模型.

主要成果:

特定的PFAS (PFOS,PFOA) 与6个月大的孩子的严重睡眠问题有关.
在12个月大的婴儿中,PFDA暴露与打风险增加有关.
PFAS混合物与6个月和12个月的更多的夜间觉醒相关.
GEE模型表明,产前 PFAS 暴露与更长的睡眠延迟,更多的觉醒,更长的清醒时间,打和更早入睡有关.

结论:

产前暴露于PFAS与婴儿睡眠障碍的风险增加有关.
研究结果强调了环境污染物对婴儿睡眠发育的潜在不利影响.

关键词:

婴儿婴儿婴儿婴儿婴儿婴儿暴露于多重污染物的暴露.和多醇基物质是多和多的.在产前,产前生育.睡眠障碍睡眠障碍睡眠障碍

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