工程,模块化神经网络的结构-功能动态,具有可控制的外接-外接连接
Nicolai Winter-Hjelm1, Åste Brune Tomren2, Pawel Sikorski2
1Department of Neuromedicine and Movement Science, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology (NTNU), Trondheim, Norway.
Journal of neural engineering
|July 3, 2023
概括
这项研究引入了一种微流体装置,指导神经网络的发展,使控制的连接和更高效的模块化网络组织能够用于研究大脑电路.
科学领域:
- 神经科学是一个神经科学.
- 生物工程是生物工程.
- 系统生物学 系统生物学
背景情况:
- 带有微电极阵列的微流体设备是体外神经网络研究的先进工具.
- 工程神经网络模仿大脑拓,但它们的功能影响尚不清楚.
- 控制网络连接对于研究神经元组合组织至关重要.
研究的目的:
- 开发一种微流体装置,用于在工程神经网络中控制 afferent 连接.
- 研究网络拓如何影响功能组织和动态.
- 为研究神经元组合在微和中等尺度上提供一个模型系统.
主要方法:
- 使用微流体装置,采用特斯拉式的道,用于单向轴突外生长.
- 雇佣设计师病毒工具用于光神经元标签和结构可视化.
- 使用纳米孔微电极进行了细胞外电生理学记录,以评估网络功能.
主要成果:
- 通过几何上受约束的轴突引导通道实现了对 afferent 连接的有效控制.
- 与单节点控制相比,证明了增强的网络模块化和效率.
- 在电刺激时观察到神经元群体之间的前信号传输.
结论:
- 开发的微流体装置可以精确控制和纵向研究神经网络结构和功能.
- 这个模型系统为神经元组件的发展,组织和神经可塑性提供了新的见解.
- 促进健康和乱状态中微型和中型神经网络的研究.
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