评估社区供水和卫生设施的获取与抗生素耐药性的全球负担之间的关系:一项生态研究
Erica R Fuhrmeister1, Abigail P Harvey2, Maya L Nadimpalli3
1Department of Civil and Environmental Engineering, University of California, Berkeley, CA, USA; Department of Environmental and Occupational Health Sciences, School of Public Health, University of Washington, Seattle, WA, USA.
The Lancet. Microbe
|July 3, 2023
概括
改善获得水和卫生设施的机会与人类抗生素耐药性基因的减少有关. 这一发现对于打击抗生素耐药性至关重要,尤其是在全球资源较少的环境中.
科学领域:
- 环境微生物学环境微生物学
- 公共卫生 公共卫生
- 传染病流行病学 传染病流行病学
背景情况:
- 抗生素耐药性是全球主要的健康威胁,不成比例地影响着低资源环境.
- 关于水,环境卫生和卫生 (WASH) 对人类抗生素耐药性的影响的证据有限.
- 这项研究调查了社区WASH接入和抗生素耐药性基因 (ARG) 负担之间的联系.
研究的目的:
- 确定人类抗生素耐药性与社区获得饮用水和卫生设施之间的关系.
- 在全球范围内分析ARG丰富度和WASH基础设施之间的关联.
主要方法:
- 生态研究设计,将人类便元基因组与家庭对WASH接入的调查数据联系起来.
- 利用NCBI序列读取档案中的公开可用的元基因组数据.
- 采用了通用线性模型来评估ARG丰富度与社区级WASH覆盖率之间的关联.
主要成果:
- 分析包括来自26个国家的1589个元基因组,在非洲观察到的ARG丰度最高.
- 获得改善的水和卫生设施的增加与较低的ARG丰度相关 (影响估计为-0.22).
- 改善的WASH和减少的ARG之间的关联在城市地区比农村地区更强.
结论:
- 研究结果表明,改善获得水和卫生设施的机会可能是减轻抗生素耐药性扩散的可行策略.
- 需要进一步的研究来确定因果关系.
- 在低收入和中等收入国家,WASH干预可以成为控制抗生素耐药性的关键组成部分.
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