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在静脉内德克萨米他植入物之前和之后对表血管质细胞的变化的评估:一个OCT试点研究
Gilda Cennamo1, Lucia Montanaro1, Luigi Massa1
1Department of Neurosciences, Reproductive and Odontostomatological Sciences, Federico II University, Naples, Italy.
Photodiagnosis and photodynamic therapy
|July 3, 2023
概括
在糖尿病视网膜病变患者中,静脉内德克萨米他植入物减少了血管质细胞和改善了视力. 这种治疗有效地向视网膜炎症和与这种疾病相关的解剖学变化.
科学领域:
- 眼科医生 眼科 眼科
- 视网膜疾病 视网膜疾病
- 医疗成像医学成像
背景情况:
- 糖尿病视网膜病变 (DR) 涉及视网膜炎症.
- 副血管质细胞 (EVG) 激活是这种炎症的一个迹象.
- 检测和治疗EVG可能会改善DR结果.
研究的目的:
- 为了检测糖尿病视网膜病变 (DR) 后的内德克萨米他松植入后的脑血管质细胞 (EVG) 变化.
- 为了将EVG变化与功能和结构改进相关联.
- 使用面对面的光学连贯断层扫描 (面对面的OCT) 和OCT血管学 (OCTA) 进行检测.
主要方法:
- 对38个患有DR和黄斑的眼睛进行前性研究,与18个健康对照对比.
- 基线测量包括骨无血管区 (FAZ) 区域,EVG存在和斑点厚度.
- 这些参数的变化在静脉内德克萨米他植入后被评估.
主要成果:
- 在基线时,FAZ较大,EVG仅在DR组中存在.
- 在治疗后三个月,视力敏度有所改善,斑点厚度显著降低 (P<0.0001).
- FAZ区域没有显著变化,但80%的患者的EVG消失了.
结论:
- 在DR中的质细胞激活可以用面对面的OCT检测到血管质细胞.
- 静脉内甲松植入物改善了DR患者的解剖和功能状况.
- 德克萨米他植入物有效地减少了像EVG这样的炎症迹象.
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