产前感染与青少年行为之间的关联:调查多个产前,产周和儿童时期的第二次打击
Anna Suleri1, Tonya White1, Elisabet Blok1
1Erasmus University Medical Center, Rotterdam, the Netherlands.
概括
产前感染与青少年的行为问题有关,特别是内化问题. 母亲因素,如药物使用和创伤,可以加剧这些风险,突出显示产前感染是心理病理的潜在风险因素.
科学领域:
- 神经科学是一个神经科学.
- 流行病学 流行病学
- 发展心理学 发展心理学
背景情况:
- 产前接触感染是一种可疑的后代心理病理的危险因素.
- 关于产前感染和长期行为结果的大规模流行病学数据有限.
研究的目的:
- 调查产前感染与青少年行为之间的关联.
- 探索这种关系中的潜在调解途径和调节因素 (第二次打击).
主要方法:
- 使用了一个潜在的怀孕队列 (R世代,n=2,213).
- 产前感染得分是基于每个三个月的感染而创建的.
- 青少年行为 (总体,内化,外化问题,自闭症特征) 在13-16岁时被评估.
主要成果:
- 产前感染与青少年总体,内化和外化问题增加有关.
- 母亲的精神病理,物质使用和童年创伤缓和了产前感染和内化问题之间的联系.
- 没有发现与自闭症特征的直接关联,但结合产前感染和不良暴露增加了风险.
结论:
- 产前感染可能是后来的精神问题的一个危险因素.
- 它可以为个人提供原始信息,增加对随后环境暴露的不良结果的易感性.
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