扩散性粒子透到细菌生物膜中
Ambika Somasundar1,2, Boyang Qin1,3, Suin Shim1
1Department of Mechanical and Aerospace Engineering, Princeton University, Princeton, New Jersey 08544, United States.
ACS applied materials & interfaces
|July 3, 2023
概括
这项研究表明,化学梯度如何将粒子移动到细菌生物膜中,使它们更容易受到抗微生物药物的攻击. 用脱离离子水进行预条件是生物膜控制的粒子运输的关键.
科学领域:
- 微生物学 微生物学
- 材料科学 材料科学 材料科学
- 化学工程是化学工程的重要组成部分.
背景情况:
- 细菌生物膜占主导地位,形成保护性的细胞外聚合物矩阵,阻碍抗微生物的透和表面去除.
- 生物膜对抗生素的反抗性需要新的控制策略,例如破坏矩阵以增强抗菌疗效.
- 粒子透到生物膜是一种有希望的,但尚未被充分探索的,用于生物膜控制的方法.
研究的目的:
- 研究使用外部施加的化学梯度来将颗粒运送到细菌生物膜中的方法.
- 确定预条件化步骤在促进生物膜吸收颗粒中的作用.
- 记录生物膜中的粒子运输行为及其潜在的逆转.
主要方法:
- 使用的聚乙烯微和纳米颗粒.
- 应用脱离离子水预洗,然后进行电解质诱导的化学梯度.
- 使用各种粒子和化学物质观察细菌生物膜内外的粒子运动.
主要成果:
- 脱离离子水的预条件对于使生物膜能够通过化学梯度吸收颗粒至关重要.
- 证明了控制的粒子传输到生物膜矩阵中.
- 记录了在特定条件下从生物膜中反转粒子运动的情况.
- 突出了化学梯度在破坏生物膜矩阵和管理粒子运输中的作用.
结论:
- 化学梯度对于破坏生物膜矩阵和调节复杂生物环境中的粒子运输至关重要.
- 通过化学渐变剂促进的颗粒物进入生物膜的运输可以增加对抗微生物素的敏感性.
- 这种方法有可能在生理系统中用于粒子和药物输送.
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