卫生技术评估中的人口调整间接比较:方法论系统性审查
Bang Truong1,2, Lan-Anh T Tran3, Tuan Anh Le4
1Faculty of Pharmacy, HUTECH University, Ho Chi Minh City, Vietnam.
Research synthesis methods
|July 3, 2023
概括
在卫生技术评估 (HTA) 中,经人口调整的间接比较 (PAIC) 显示行为和报告不足最佳. 制药公司主要进行这些分析,对人口对齐和异质性评估的方法不一致,需要改进指南.
科学领域:
- 医疗技术评估 (HTA) 是指对医疗技术进行评估.
- 相对有效性研究研究比较
- 生物统计学和流行病学
背景情况:
- 人口调整间接比较 (PAIC) 越来越多地用于HTA,以解决研究之间的目标人群差异.
- 在当前的HTA实践中,PAIC的方法严谨性和报告质量需要进行系统的评估.
研究的目的:
- 在最近的卫生技术评估中评估PAIC的行为和报告实践.
- 确定 PAIC 实施的方法和透明度需要改进的领域.
主要方法:
- 对实施PAICs的研究进行了一项方法系统审查.
- 在PubMed,EMBASE,Ovid Medline All和Cochrane数据库 (2010年1月1日 - 2023年2月13日) 中进行了搜索.
- 四名独立研究人员从106篇符合条件的文章中提取了有关方法和报告特征的数据.
主要成果:
- 绝大多数 (96.9%) 的PAIC分析是由制药公司进行或资助的.
- 对人口调整的预调整方法应用不一致 (44.5%),对异质性的广泛评估不常见 (37.0%).
- 个体研究质量/偏差评估 (9.3%) 和模型拟合程序的充分报告 (16.7%) 特别低.
结论:
- 在当前的HTA实践中,PAIC的行为和报告的特点是显著的异质性和低于最佳的质量.
- 显然需要加强推和指导方针,以提高PAIC在卫生技术评估中的质量和可靠性.
更多相关视频
08:36Author Spotlight: Evaluating the Adjuvant Efficacy and Safety of Angong Niuhuang Pill in Viral Encephalitis Treatment
Published on: April 19, 2024
607
06:05The Participant-Reported Implementation Update and Score PRIUS: A Novel Method for Capturing Implementation-Related Data Over Time
Published on: February 19, 2021
1.3K
相关概念视频
01:23Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches
148
Biopharmaceutical studies constitute a vital field aiming to enhance drug delivery methods and refine therapeutic approaches, drawing upon diverse interdisciplinary knowledge. In research methodologies, the choice between controlled and non-controlled studies significantly influences the study's reliability and accuracy.
Non-controlled studies, commonly employed for initial exploration, lack a control group, rendering them susceptible to biases and external influences. In contrast,...
Non-controlled studies, commonly employed for initial exploration, lack a control group, rendering them susceptible to biases and external influences. In contrast,...
148
01:12Analysis of Population Pharmacokinetic Data
300
Analysis of population pharmacokinetic data involves studying the behavior of drugs within diverse populations to understand their pharmacokinetic parameters. Traditional pharmacokinetic methods typically involve collecting samples from a few individuals and estimating these parameters. While these methods are commonly used, they have limitations in capturing the variability in drug response among individuals or heterogeneous populations. Population pharmacokinetics is employed to address these...
300
01:20Comparing the Survival Analysis of Two or More Groups
227
Survival analysis is a cornerstone of medical research, used to evaluate the time until an event of interest occurs, such as death, disease recurrence, or recovery. Unlike standard statistical methods, survival analysis is particularly adept at handling censored data—instances where the event has not occurred for some participants by the end of the study or remains unobserved. To address these unique challenges, specialized techniques like the Kaplan-Meier estimator, log-rank test, and...
227
01:12Hazard Ratio
165
The hazard ratio (HR) is a widely used measure in clinical trials to compare the risk of events, such as death or disease recurrence, between two groups over time. It reflects the ratio of hazard rates—the instantaneous risk of the event occurring—between a treatment group and a control group. This measure provides valuable insights into the relative effectiveness of a treatment by assessing how the risk of an event differs between the two groups.
For example, in a clinical trial...
For example, in a clinical trial...
165
01:26Pharmacokinetic Models: Comparison and Selection Criterion
109
Physiological and compartmental models are valuable tools used in studying biological systems. These models rely on differential equations to maintain mass balance within the system, ensuring an accurate representation of the dynamic processes at play.
Physiological models take a detailed approach by considering specific molecular processes. They can predict drug distribution, metabolism, and elimination changes, providing a comprehensive understanding of how drugs interact with the body.
Physiological models take a detailed approach by considering specific molecular processes. They can predict drug distribution, metabolism, and elimination changes, providing a comprehensive understanding of how drugs interact with the body.
109
01:52Regression Toward the Mean
6.3K
Regression toward the mean (“RTM”) is a phenomenon in which extremely high or low values—for example, and individual’s blood pressure at a particular moment—appear closer to a group’s average upon remeasuring. Although this statistical peculiarity is the result of random error and chance, it has been problematic across various medical, scientific, financial and psychological applications. In particular, RTM, if not taken into account, can interfere when...
6.3K