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下一代测序分析及其对肺腺癌瘤向治疗的益处

Vlastimil Kulda¹, Jiri Polivka^2,3, Martin Svaton⁴

¹Department of Medical Chemistry and Biochemistry, Faculty of Medicine in Pilsen, Charles University, Pilsen, Czech Republic.

Cancer genomics & proteomics

|July 3, 2023

概括

下一代测序 (NGS) 识别了肺腺癌中的可向突变,通过向疗法显著改善了患者的治疗结果. 这些先进治疗方法的可用性在过去五年中显著增加.

科学领域:

在瘤学瘤学.
基因组学就是基因组学.
个性化医疗是个性化的医疗.

背景情况:

肺腺癌是最常见的肺癌亚型.
针对性治疗的选择以通过下一代测序 (NGS) 识别的遗传改变为指导.

研究的目的:

使用NGS分析肺腺癌组织中的突变.
评估针对性治疗对患者的好处.
评估五年来针对性治疗的可用性变化.

主要方法:

使用Archer FusionPlex CTL面板进行NGS分析.
研究队列包括237名在2018年至2020年期间接受治疗的肺腺癌患者.

主要成果:

在57%的患者中检测到基因变异;5.9%的融合基因.
34名患者 (14.3%) 具有可向变异,接受特定疗法 (EGFR,EML4-ALK,CD74-ROS1).
与化疗相比,针对性治疗显著改善了EGFR或EML4-ALK变异的晚期患者的预后.
到2023年5月,针对性治疗的潜在受益者增加了88%.

结论:

肺腺癌患者从向治疗中获得显著益处.
基于NGS的突变分析对常规瘤患者管理至关重要.

关键词:

没有NGS,没有NGS.肺部腺癌的癌症预后预后预后有针对性的治疗.

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