在患有焦点前时神经退行症的患者中表达性形
Amandine Geraudie1, Peter S Pressman1, Jérémie Pariente1
1From the Memory and Aging Center (A.G., E.R.P., B.M.R., G.B., M.L.M., Z.A.M., B.L.M., V.S., K.P.R., M.L.G.-T., M.M.), Department of Neurology, University of California San Francisco; Neurology Department (A.G., J.P.), Toulouse University Hospital; Institut du Cerveau (ICM) (A.G.), INSERM U1127, CNRS UMR 7225, Sorbonne Université, Paris, France; Department of Neurology (P.S.P.), University of Colorado; Department of Speech (C.M.), Language, and Hearing Sciences, The University of Texas at Austin; Dyslexia Center (E.R.P., M.L.M., Z.A.M., V.S., M.L.G.-T.), Department of Neurology, University of California San Francisco; Department of Otolaryngology-Head and Neck Surgery (G.B.), Massachusets Eye and Ear and Harvard Medical School, Boston; Douglas Research Centre (M.M.); and Department of Psychiatry (M.M.), McGill University, Montréal, Quebec, Canada.
语义行为变体前性痴呆症 (sbvFTD) 患者在他们的言语中显示出降低的音调变化 (f0范围). 这一发现表明,表达式的表情变化可能有助于诊断sbvFTD,并了解其与同理心和右叶功能之间的联系.
科学领域:
- 神经科学是一个神经科学.
- 语言学的语言学.
- 心理学 心理学 心理学
背景情况:
- 语义性痴呆症,现在被称为语义变体初级渐进性失语症 (svPPA) 和语义行为变体前性痴呆症 (sbvFTD),涉及前叶 (ATL) 神经退行.
- 目前缺乏与右ATL神经退行相关的sbvFTD的准确诊断工具.
- 表达式的表情,对于传达情感和语言信息至关重要,与右主导的前功能有关,可以使用声学方法测量.
研究的目的:
- 与健康对照人群相比,研究svPPA和sbvFTD患者表达性表情变化.
- 在这些患者群体中探索前测量,同情和大脑结构之间的关系.
主要方法:
- 对28名svPPA患者,18名sbvFTD患者和18名健康对照 (HC) 进行了神经心理和语言评估和3T MRI.
- 从口头描述中提取了基本频率 (f0) 范围,即音调变化的度量.
- f0范围在各组之间进行了比较,并通过基于voxel的形态测量与告密者评级的同理心,面部情感标记和灰质 (GM) 量相关联.
主要成果:
- 与svPPA患者和HCs患者相比,sbvFTD患者的f0范围显著减少.
- 较高的f0范围与信息人评级的同理心有积极的相关性.
- 降低的f0范围与右上旋中较低的灰质体积有关.
结论:
- 表达式表情的变化,特别是降低音调变化,可以作为sbvFTD的有价值的临床标志物.
- 这些发现将前性缺陷与 Empathy 的减少联系起来,并突出了右上叶在 sbvFTD 中的作用.
- 表达式前分析为评估sbvFTD中的社会情感功能提供了一个潜在的工具.
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