针对性治疗中断后的结果在患有囊性瘤的患者中
Anne S Reiner1, Benjamin H Durham2,3, Mariko Yabe2
1Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
British journal of haematology
|July 3, 2023
概括
针对性治疗中断的质细胞瘤往往导致复发. 然而,达到完全反应,具有非BRAFV600E突变或仅MEK抑制可能会改善结果.
科学领域:
- 在瘤学瘤学.
- 血液学 血液学 血液学
- 药理学 药理学是指药理学的学科.
背景情况:
- 暂停针对性治疗质细胞瘤后的结果尚不清楚.
- 囊性瘤是罕见的,需要有效的治疗策略.
研究的目的:
- 在成年患有囊胞性瘤的患者中,研究BRAF和MEK抑制剂中断后的疾病复发和存活率.
- 为了确定与治疗停止后改善无复发存活率相关的因素.
主要方法:
- 对22名患有囊胞性瘤的成年患者进行了回顾性研究.
- 治疗中断发生在通过18-fluorodeoxyglucose正子发射断层扫描 (FDG-PET) 评估的完全或部分反应后.
- 基于反应,突变状态和接受治疗的无复发存活率的分析.
主要成果:
- 在治疗中断后,17/22 (77%) 的患者出现了疾病复发.
- 在中断前的完整反应,非BRAFV600E突变和单独的MEK抑制与明显更好的无复发存活率有关.
- 对特定患者来说,限时向治疗可能是可行的.
结论:
- 在停止针对性治疗质细胞瘤后,复发是经常发生的事件.
- 患者特定的因素和治疗方案会影响持续缓解的可能性.
- 需要进一步的研究来优化治疗持续时间和管理策略.
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