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PD-1/PD-L1封锁恢复了瘤诱导的COVID-19疫苗的直接性

Xiangyu Chen¹, Yao Lin², Shuai Yue³

¹School of Basic Medical Sciences, Southern Medical University, Guangzhou 510515, China.

|July 3, 2023

概括

癌症患者已经降低了COVID-19疫苗的有效性. PD-1/PD-L1免疫检查点阻塞疗法可以通过提高T细胞活性来恢复疫苗反应,独立于抗瘤效应.

科学领域:

免疫学免疫学免疫学
在瘤学瘤学.
疫苗学疫苗学疫苗学

背景情况:

COVID-19疫苗对于大流行控制至关重要.
癌症患者显示COVID-19疫苗的有效性降低.
PD-1/PD-L1免疫检查点阻塞 (ICB) 疗法在治疗各种癌症方面表现有前途.

研究的目的:

研究PD-1/PD-L1 ICB治疗对癌症患者COVID-19疫苗有效性的影响.
探索疫苗反应中任何观察到的变化背后的机制.

主要方法:

使用了临床前癌症模型.
根据PD-1/PD-L1 ICB治疗的存在和缺乏,评估了COVID-19疫苗的反应.
分析了免疫细胞群,特别是毛囊辅助T细胞和生殖中心反应.

主要成果:

在临床前模型中,PD-1/PD-L1 ICB疗法在很大程度上逆转了被抑制的COVID-19疫苗反应.
恢复疫苗的有效性是独立于ICB治疗的抗瘤作用.
从机制上讲,恢复的疫苗反应与卵泡辅助T细胞和生殖中心活动的增加有关.

结论:

PD-1/PD-L1阻塞可以使癌症患者的COVID-19疫苗反应正常化.
这种疫苗反应的正常化是无论治疗的抗瘤疗效如何实现的.
这些发现突出了提高免疫功能受损的癌症人群疫苗疗效的潜在策略.

关键词:

这是COVID-19疫苗.癌症免疫疗法癌症免疫疗法在PD-1/PD-L1上进行封锁.在SARS-CoV-2 RBD中.在T (FH) 细胞中.

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