静脉注射免疫球蛋白治疗抗中性粒细胞体抗体相关的血管炎
Fabricio Benavides-Villanueva1, Javier Loricera1, Vanesa Calvo-Río1
1Rheumatology Division, Hospital Universitario Marqués de Valdecilla, IDIVAL, Valdecilla s/n., ES- 39008, Santander, Spain.
European journal of internal medicine
|July 3, 2023
概括
静脉注射免疫球蛋白 (IVIG) 为复发性或耐火性抗中性粒细胞抗体 (ANCA) 相关血管炎 (AAV) 提供安全有效的治疗方法. 此疗法还有助于与AAV.一起管理活跃感染.
科学领域:
- 类风湿病学 类风湿病学
- 免疫学 免疫学 免疫学
- 内部医学 内部医学
背景情况:
- 抗中性粒细胞质抗体 (ANCA) 相关血管炎 (AAV) 包含三个具有挑战性的临床条件.
- 有限的数据存在于静脉注射免疫球蛋白 (IVIG) 作为AAV的治疗选择.
研究的目的:
- 在现实临床环境中评估IVIG在AAV患者的有效性和安全性.
- 评估IVIG对疾病活性和葡萄糖皮质醇需求的影响.
主要方法:
- 一项单一中心的观察性研究包括28名在2000年至2020年期间接受IVIG治疗的AAV患者.
- 使用伯明翰血管炎活动评分 (BVAS) 测量疾病活性,以及CRP和ESR水平.
- 给出了不同的IVIG剂量方案,有效性在1,6,12,24个月后进行评估.
主要成果:
- 观察到BVAS得分的显著和持续改善,从1个月后的34.6%到2年后的56.5%.
- 通过IVIG治疗导致葡萄糖皮质醇剂量减少.
- 治疗耐受性很好,有轻度和不常见的不良反应.
结论:
- 静脉注射免疫球蛋白 (IVIG) 证明了作为治疗复发性/耐药性AAV的疗效和安全性.
- IVIG是一种可行的治疗替代方案,特别是在AAV患者中存在活跃感染时.
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