在Auryon激光切除术后,使用微型CT和组织学评估治疗膝下中间动脉化的治疗效果
John Rundback1, Kenji Kawai2, Yu Sato2
1Advanced Interventional & Vascular Services LLP, Teaneck, NJ, USA.
概括
在人类尸体中,Auryon激光除骨折的中枢动脉化. 这种激光疗法有效地治疗了化病变,特别是那些持续环形化病变,显示出对外周动脉疾病的希望.
科学领域:
- 血管外科 血管外科
- 干预心脏病学 干预心脏病学
- 生物医学工程 生物医学工程
背景情况:
- 中枢动脉化 (MAC) 是外围动脉疾病 (PAD) 的重要因素.
- 动脉切除器件的目的是去除或修改化病变以改善血液流动.
- 奥里昂激光系统是一种用于治疗化动脉疾病的新型切除术技术.
研究的目的:
- 为了评估Auryon激光切除术在中枢动脉化断裂中的有效性.
- 通过微计算机断层扫描 (微CT) 和组织学来评估MAC骨折的频率.
- 在人类尸体模型中研究易受奥里昂激光破裂的化病变的特征.
主要方法:
- 人体尸体下膝关节动脉段与化被用奥里昂激光系统处理.
- 治疗包括单独使用Auryon激光或与普通气球血管整形 (POBA) 结合使用.
- 在治疗前和治疗后进行了微型CT,血管学和组织学评估,以评估破坏.
主要成果:
- 奥里恩激光切除术成功治疗了所有9个动脉段.
- 微型CT分析显示,在9个治疗区中的6个 (在36个评估区中的18个) 发现了骨折.
- 断裂化与明显更流动,不间断的环形化 (较大的弧度) 相关,不管负担如何. 没有发生剖析或破裂.
结论:
- 在人类动脉样硬化模型中,奥里昂激光切术证明了破裂中枢动脉化的能力.
- 激光在破坏MAC的有效性似乎取决于化的模式,特别是环形和不间断的病变.
- 这些发现表明,Auryon激光系统作为对挑战性化外围动脉病变的治疗选择具有前途.
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