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偏向男性的肠道微生物群和代谢物加剧结肠直肠癌的发展

Ling Wang^1,2,3, Yi-Xuan Tu^1,2, Lu Chen^1,2

¹Hubei Hongshan Laboratory, Wuhan, 430070, China.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)

|July 3, 2023

概括

男性的结肠直肠癌 (CRC) 发病率较高. 这项研究揭示了性别偏见的肠道微生物和代谢物驱动这种差异,建议针对CRC的向疗法.

科学领域:

胃肠病学胃肠病学
微生物组研究微生物组研究
癌症生物学癌症生物学

背景情况:

结肠直肠癌 (CRC) 的发病率和死亡率在男性中高于女性.
在CRC中这种性二态的根本原因仍然不完全理解.

研究的目的:

调查性偏见性肠道微生物群和代谢物在结肠直肠癌 (CRC) 性变异中的作用.
阐明导致男性CRC风险和严重程度增加的机制.

主要方法:

利用ApcMin/+和阿佐克西甲 (AOM) /德克斯硫酸 (DSS) 的小鼠模型来研究结直肠瘤发生.
使用伪细菌小鼠与男性或女性捐赠者 (小鼠或患者) 的便样本结合殖民,以评估肠道屏障功能和炎症.
分析了肠道微生物群的组成,并确定了参与性别偏差瘤发生的关键代谢物.

主要成果:

雄性小鼠的结直肠瘤显着更大,更多,以及肠道屏障功能受损.
接受雄性便样本的伪细菌小鼠显示肠道损伤和炎症恶化.
在男性中发现了Akkermansia muciniphila的增加和Parabacteroides goldsteinii的减少,性别偏差的代谢物影响了糖脂代谢.

结论:

性偏见的肠道微生物组和代谢物是结直肠癌 (CRC) 性变态的关键贡献者.
针对这些性别偏差的微生物和代谢变化,为CRC提供了潜在的治疗策略,以适应性别特异性差异.

关键词:

结肠直肠癌是什么意思便微生物群移植我们的肠道微生物组.性二重形性质性质二重形性质.

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