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Updated: Jul 24, 2025

Identification of Transcription Factor Regulators using Medium-Throughput Screening of Arrayed Libraries and a Dual-Luciferase-Based Reporter
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通过大规模的功能性表观遗传学屏幕揭示了YAP响应元素的癌症谱系特定调节

Inês A M Barbosa1, Rajaraman Gopalakrishnan2,3, Samuele Mercan1

  • 1Disease Area Oncology, Novartis Institutes for Biomedical Research, Basel, Switzerland.

Nature communications
|July 3, 2023
PubMed
概括

YAP蛋白对癌细胞生长至关重要. 虽然在恶性多层层层髓瘤 (MPM) 和膜层黑色素瘤 (UM) 中是必不可少的,但其与TEAD的相互作用在UM中是不可缺少的,影响了向治疗.

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